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Dr. Barzilai’s work with centenarians, people who have reached the age of 100, forms a significant part of the book. Through his research, he has identified common traits among centenarians, including specific genetic markers, lifestyle factors, and environmental influences that contribute to their exceptional longevity. These findings offer valuable insights into the factors that could help us live longer, healthier lives. Interventions and pharmacology There are two main classifications of naturally occurring stem cells: embryonic stem cells and adult stem cells (a.k.a. somatic stem cells). Over the past forty years, researchers have discovered that the adult brain - which we once believed to be "hardwired" in its perceptions and responses - can, in fact, continue to forge new connections well into old age, changing neural pathways and creating new possibilities for how we experience and respond to everything from sensory stimuli to life events." (p 184) I hear–you can ask your doctor to be safe–that taking two 400 mg Vitamin E pills helps with hot flashes. A woman who’s a few years older than me told me this.
Best Longevity Books (15 books) - Goodreads Best Longevity Books (15 books) - Goodreads
In Young Forever , Dr. Mark Hyman challenges us to reimagine our biology, health, and the process of aging. To uncover the secrets to longevity, he explores the biological hallmarks of aging, their causes, and their consequences—then shows us how to overcome them with simple dietary, lifestyle, and emerging longevity strategies. You’ll learn: Antioxidants - found, for example, in vitamins E and C - help the body fight the damaging effects of oxidation, a natural process that occurs in your cells when they produce energy." (p. 79) Jim Mellon’s name may be familiar to you if you’ve been following the life extension space for a while, and it’s because the British billionaire has himself co-founded a longevity-focused biotech company named, aptly, Juvenescence, and invested in others like AgeX Therapeutics. He’s also donated to Aubrey de Grey’s SENS Research Foundation, the Institute of Healthy Ageing at UCL, and the Methuselah Foundation. Our bodies weaken naturally, and ageing puts us at risk of a host of diseases, but a risk factor is not a diagnosis. It's a call to action ... Knowing the risks can empower us to become the architects of our own strength and resilience." (p. 40)
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This 2016 aging book by theoretical-biologist Josh Mitteldorf and co-author Dorion Sagan (son of Carl Sagan) has new relevance for life extension after the pre-publication, in May 2020, of a paper whose results seem to vindicate at least a portion of Mitteldorf’s theory of aging. It was the beginning of simplifying my relationship with my own health, and of focusing on a few things that matter. It was also the beginning of my personal friendship with Howard, which is one of the recent delights of my life. Dr. Barzilai, who founded the Institute for Aging Research at the Albert Einstein College of Medicine, is another giant in the life extension research space (he’s running the TAME trial to see if metformin has anti-aging effects on humans), and his new book covers all his aging research findings and possible applications.
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Emotional Health: Attia underscores the necessity of nurturing emotional well-being for a fulfilling, long life. He suggests practicing mindfulness techniques, such as meditation and gratitude journaling, prioritizing social connections, and engaging in leisure activities to foster emotional resilience and reduce stress. I really enjoyed reading The Body Book but I feel like the focus in that novel was largely on nutrition and fitness. With this novel, as much of both of those do have a huge component on longevity in life, I found the information provided was expanded to a more holistic outlook of the whole body.As we age, most of our organs get smaller and our muscles get smaller, while we gain more fat. This shift in body composition contributes to a loss of energy expenditure that makes it easier for you to gain weight. (Muscle burns more energy than fat, and so does metabolically active tissue and organs. So less lean body mass means a lower resting metabolic rate.) And I was wrong, as I learned from discussions with Howard years ago. What I was doing was stressing my body in ways that guaranteed injuries, at best, and, at worst, could put me on the path to cardiac irregularities and even an early death. That’s the path I was unknowingly on. A]geing is the biggest single risk factor for chronic illnesses like cardiovascular disease, cancer, type 2 diabetes, osteoporosis, and neurodegeneration (including Alzheimer's)." (p. 38)
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